Dr. Mikhail Blagosklonny is an oncology Professor at Roswell Park Institute of Cancer; New York. He is also a cancer scientist specialized in the aging and cancer studies. Blagosklonny is an M.D., Ph.D. graduate in Cardiology/Medicine from the Medical University; Pavlov, St. Petersburg. He was selected as a Medicine Professor at the College of Medicine; New York in 2002.
Dr.Blagoskonny was also a scientist at the O.R Institute in Albany; New York. He was confirmed in 2009 as an Oncology Professor at the prestigious Cancer Institute; Roswell Park. Dr. Mikhail Blogosklonny’s research focuses on possible cancer remedies and the principal methods of growing old and anti-age medication.
Cancer Aging and Rapamycin
Blagosklonny created a hypothesis focusing on TOR signals role in cancer and aging as well as the proposed rapamycin, an accepted cancer medicine, a promising treatment therapy for the extension of life. Blagosklonny is Chief Editor of the Aging Cell Cycle and Oncotarget as well as the Editorial Associate of Cancer Therapy and Biology. He also serves on the Cell Death Editorial Board.
Mikhail’s role at the Roswell Park Cancer Institute
Mikhail was appointed as an Associate Professor of Oncology at the Roswell Park Cancer Institute on April 15, 2009 on ResearchGate.net. Misha is a paramount researcher in the development of cancer concepts in biology and therapy. His presence at Roswell Park facilitates the advancement of innovative anti-cancer stratagem and cancer treatment and prevention methods.
Blagosklonny’s Hypothesis about the Possible Role of TOR Signaling in Aging and Cancer
Aging is understood from the evolution point of view. Organisms in the wild do not live long to experience aging. Therefore only in the protected environment do humans and domestic animals die from aging.
The TOR nutrient-sensing pathway is triggered by nutrients, insulin, and growth factors. In turn, it increases protein synthesis, stimulates cell mass growth and, induces buildup of growth proteins, and causes resistance to insulin and GF.
In short, TOR causes cell hyper-functions to each particular tissue such as bone by soft muscle cells, and visible osteoporosis. This ultimately damages organs (aging- disaster) leading to age-related illnesses. The TOR passage is implicated in diseases like cancers, diabetes type II, age-related muscular degeneration, organ failure (liver, renal and cardiac), Alzheimer’s and arthritis.
The theory that aging isn’t motivated by the accumulation of accidental damage best explains hormesis. Category A Hormesis upsets the TOR pathway. Category B Hormesis cause damaging anxiety. Aging is not brought about by loss, but it may cause the acceptance of aging, therefore protecting humans from dangerous aging-induced disasters. Source: http://www.nature.com/cdd/about/biographies.html